Moodle - Gyan Ganga Group

Unit-I

Controlled drug delivery systems: Introduction, terminology/definitions and

rationale,advantages, disadvantages, selection of drug candidates. Approaches

to design controlled release formulations based on diffusion, dissolution and ion

exchange principles. Physicochemical and biological properties of drugs

relevant to controlled release formulations

Polymers: Introduction, classification, properties, advantages and application of

polymers in formulation of controlled release drug delivery systems.

Unit-II

Microencapsulation: Definition, advantages and disadvantages, microspheres

/microcapsules, microparticles, methods of microencapsulation, applications

Mucosal Drug Delivery system: Introduction, Principles of bioadhesion /

mucoadhesion, concepts, advantages and disadvantages, transmucosal

permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems:Introduction, advantages and

disadvantages, concept of implantsand osmotic pump

Unit-III

Transdermal Drug Delivery Systems: Introduction, Permeation through skin,

factors affecting permeation, permeation enhancers, basic components of

TDDS, formulation approaches

Gastroretentive drug delivery systems: Introduction, advantages,

disadvantages, approaches for GRDDS – Floating, high density systems,

inflatable and gastroadhesive systems and their applications

Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary

routes of drug delivery, Formulation of Inhalers (dry powder and metered dose),

nasal sprays, nebulizers

Unit-IV

Targeted drug Delivery: Concepts and approaches advantages and

disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal

antibodies and their applications

Unit-V

Ocular Drug Delivery Systems: Introduction, intra ocular barriers and

methods to overcome –Preliminary study, ocular formulations and ocuserts

Intrauterine Drug Delivery Systems: Introduction, advantages and

disadvantages, development of intra uterine devices (IUDs) and applications

Scope:This subject is designed to impart knowledge and skills necessary for dose calculations, dose adjustments and to apply Biopharmaceutics theories in practical problem solving. Basic theoretical discussions of the principles of Biopharmaceutics and pharmacokinetics are provided to help the students’ to clarify the concepts. 

Objectives: Upon completion of the course student shall be able to: 1. Understand the basic concepts in biopharmaceutics and pharmacokinetics. 2. Use plasma data and derive the pharmacokinetic parameters to describe the process of drug absorption, distribution, metabolism and elimination. 3. Critically evaluate biopharmaceutic studies involving drug product equivalency 4. Design and evaluate dosage regimens of the drugs using pharmacokinetic and biopharmaceutic parameters. 5. detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them 

• Scope: This subject deals with the application of instrumental methods in qualitative and quantitative analysis of drugs. This subject is designed to impart a fundamental knowledge on the principles and instrumentation of spectroscopic and chromatographic technique. This also emphasizes on theoretical and practical knowledge on modern analytical instruments that are used for drug testing.

Objectives: Upon completion of the course the student shall be able to .

1. Understand the interaction of matter with electromagnetic radiations and its applications in drug analysis.

 2. Understand the chromatographic separation and analysis of drugs. 

3. Perform quantitative & qualitative analysis of drugs using various analytical instruments.

UNIT –I 10 Hours UV Visible spectroscopy Electronic transitions, chromophores, auxochromes, spectral shifts, solvent effect on absorption spectra, Beer and Lambert’s law, Derivation and deviations. Instrumentation - Sources of radiation, wavelength selectors, sample cells, detectors- Photo tube, Photomultiplier tube, Photo voltaic cell, Silicon Photodiode. Applications - Spectrophotometric titrations, Single component and multi component analysis Fluorimetry Theory, Concepts of singlet, doublet and triplet electronic states, internal and external conversions, factors affecting fluorescence, quenching, instrumentation and applications .

UNIT –II 10 Hours IR spectroscopy Introduction, fundamental modes of vibrations in poly atomic molecules, sample handling, factors affecting vibrations Instrumentation - Sources of radiation, wavelength selectors, detectors - Golay cell, Bolometer, Thermocouple, Thermister, Pyroelectric detector and applications Flame Photometry-Principle, interferences, instrumentation and applications 144 Atomic absorption spectroscopy- Principle, interferences, instrumentation and applications Nepheloturbidometry- Principle, instrumentation and applications 

UNIT –III 10 Hours Introduction to chromatography Adsorption and partition column chromatography-Methodology, advantages, disadvantages and applications. Thin layer chromatography- Introduction, Principle, Methodology, Rf values, advantages, disadvantages and applications. Paper chromatography-Introduction, methodology, development techniques, advantages, disadvantages and applications Electrophoresis– Introduction, factors affecting electrophoretic mobility, Techniques of paper, gel, capillary electrophoresis, applications.

 UNIT –IV 08 Hours Gas chromatography - Introduction, theory, instrumentation, derivatization, temperature programming, advantages, disadvantages and applications High performance liquid chromatography (HPLC)-Introduction, theory, instrumentation, advantages and applications.

 UNIT –V 07 Hours Ion exchange chromatography- Introduction, classification, ion exchange resins, properties, mechanism of ion exchange process, factors affecting ion exchange, methodology and applications Gel chromatography- Introduction, theory, instrumentation and applications Affinity chromatography- Introduction, theory, instrumentation and applications.

Recommended Books (Latest Editions) 

1. Instrumental Methods of Chemical Analysis by B.K Sharma

 2. Organic spectroscopy by Y.R Sharma 

3. Text book of Pharmaceutical Analysis by Kenneth A. Connors

 4. Vogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel 

5. Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake 

6. Organic Chemistry by I. L. Finar

 7. Organic spectroscopy by William Kemp 

8. Quantitative Analysis of Drugs by D. C. Garrett 

9. Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi

 10. Spectrophotometric identification of Organic Compounds by Silverstein